Mycoglannan

Mycoglannan is produced from the cell walls of inactivated baker’s

yeast (SaccharomycesCerevisiae) which has been grown by

non-­‐alcohol fermentation. The yeast cell walls are ruptured, extracted

by centrifuge and then washed, dried and pasteurized.

Additional Benefit of Toxin Binders –

​There is a second benifit from this product. The outer cell wall contains mannan protiens that can not be digested by the  horses gut, but acts as a prebiotic for the good bacteria in the gut. The good bacteria then grow quickly, providing defence against bad bacteria.

Mycoglannan Toxin Binder
What is Mycoglannan and how does it work?
Mycoglannan is produced from the cell walls of inactivated
baker’s yeast (Saccharomyces Cerevisiae), which has
been grown by non-alcohol fermentation, centrifuged and
then dried. It is made up of material, which forms 2 rings
surrounding the yeast cell wall.
The outer layer is Mannan Protein also known as
mannanoligosaccharide (MOS).
The inner layer is made up of B Glucans.
Mannan , Mannanoligosaccharides or MOS.
Mannan is a non-digestible protein carbohydrate, when
added to an animals total feed, its complex nature
prohibits it being digested by the animal, but makes it
available to be used by the good bacteria/flora of the gut.
This allows the good bacteria to grow rapidly in the gut
and provide an improved defence against harmful
bacteria. The animal is now better able to fight against bad
bugs. This is referred to as a prebiotic.
Prebiotic – A Prebiotic can be described as a biological
agent that stimulates preventative activity within the gut of
an animal.
So what is the actual process? Pathogens enter the
animals gut and look for a place on the cells which line the
gastrointestinal tract to bind and subsequently colonize
and reproduce. To prevent the establishment of the bad
bacteria, it is necessary to stop the binding process. The
Mannans do this by getting between the lectins on the bad,

bacteria and the sugar compounds on the intestinal lining.
The lectins attach to the Mycoglannan instead of the
sugars on the cell of the gut wall lining. After capturing the
pathogens, the Mycoglannan is expelled naturally by the
animal through the gut along with other waste materials.
Due to the production techniques, Mycoglannan material
is one of the most consistent and effective MOS on the
market.
What about the B-Glucans?
The inner layer of the cell wall is made up by the
extremely complex carbohydrate 1,3 1,6 Beta-glucan. It
has been shown Beta-glucans interact with the immune
system to increase its reaction capabilities.
These substances increase host immune defense by
activating complement system, enhancing macrophages
and natural killer cell function.
This is a very simplistic breakdown of how these
components work, and the research in this field is
ongoing. But very basically Mycoglannan works to activate
the animals’ immune system through the activity of betaglucans and mannans, which are two of the main
components of the yeast cell wall. These elements bind to
pathogens in the digestive tract and stimulate the immune
system to produce antibodies.
Mycoglannan material is a component of many specialty
animal feeds over seas Many of the Sheep farmers in the
UK and Ireland are using this cell wall material and finding
the benefits overwhelming. They claim that the
Mycoglannan material increases the amount of maternal

Antibodies in the colostrum the ewes are producing, giving
the lambs the best form of disease defence possible.
Am I just as well to use other toxin binders?
I have been asked about using other forms of toxin binders such
as bentonite and zeolite. Below is a study that was done in a
Brazilian university –
Carlos Alberto da Rocha Rosa DVM, Ph.D., Universidad
Federal Rural de Rio de Janeiro, Brazil -Adsorbing agents
– One of the strategies for reducing the exposure to
mycotoxins is to decrease their bioavailability by including
various mycotoxin adsorbing agents in the compound
feed, which leads to a reduction of mycotoxin uptake as
well as distribution to the blood and target organs.
Adsorbing agents are also called binding agents,
adsorbents, binders, etc. The reduction of mycotoxin
bioavailability using various inorganic adsorbents – like
bentonite and zeolites – has been thoroughly studied.
However, some of these adsorbents can reduce nutritional
value of feeds by binding trace minerals, amino acids and
vitamins and reducing their bioavailability and even
produce dioxins, produce undesirable side effects and
they are not considered safe by the European Union. Due
to the limitations of mineral adsorption, many studies have
been conducted over the last decade on biological
adsorbents, in an attempt to obtain greater efficacy and
specificity while, at the same time, reduce the impact on
nutritional quality compared to mineral adsorbents.
These are not binders we like to use full time, and you can
now see why. Within this study it was also discovered that,

the( Mycoglannan material) was affective in inhibiting the
oestrogenic effect of ZEA(zearalenone) pathogen.
As more research results are published overseas, and the
list of pathogens controlled by( Mycoglannan material)
increases, it is being mooted that the product will
eventually replace the antibiotics used as growth
stimulants. Until these claims are accepted and approved
by the APVMA, it would be prudent at this time to expect
only the following performance claims and benefits:
– helps maintain a healthy immune system
– supports natural defense
– promotes a healthy gut flora
– maintains and promotes gut health.
Introducing (Mycoglannan) to an animals feed would be
reasonable to assume prevention is better then cure.
So what pathogens are we worried about and how do
they affect the animals?
Some types of gram-negative bacteria live in the gut of the horse
but don’t cause any problems unless the horse is sick for some
other reason. At this point the bacteria start to excessively
proliferate, they breach the cell wall of the
gut and get into the blood stream. When they die off, their cell
walls rupture, releasing a toxin called lipopolysaccharide (LPS) into
the blood stream, causing endotoxemia. E.coli and Salmonella are
an example of some of these bacteria. These healthy horses will
eliminate the bacteria in their manure. Other horses and foals in
the paddocks may then eat the manure and so the bacteria is
passed on.
Some of the conditions that can lead to edotoxemia are –
– Damage to the mucous barrier in the intestines
– Inflammation of the small intestine
– Twisted gut
– Colitis (a severe intestinal condition brought on by stress)
– Acute metritis (severe inflammation of the uterus due to infection,
usually from a retained placenta)

– Infection of the umbilicus in foals
– Insufficient ingestion of colostrum in foals.
There are many groups of mycotoxins, and below is a list of a few
that are knows to affect the horses.
These are toxins that are produced from many forms of fungi and
are found in cereal crops and some in dried fruits (rose-hips are a
dried fruit!), and grasses and pastures, and hays.
Pauline from www.gravelproofhoof.org has a very good write up on
mycotoxins. Please visit this site for a great read.

So to cap off on all this informantion – Mycoglannan is a toxin
binder. It binds to many of the toxins before they get a chance to
enter the body through the cell wall of the gut. Once bound, the
body is able to eliminate the toxins via the manure.
It also enhances the antibodies the body makes to deal with the
invaders, enhancing the immunoglobulin during gestation
improving colostrum and transfer of immunity from mother to
offspring at birth.
– Improves gut health by providing to animals with a better capacity
to absorb nutrients and cope with challenging environmental
conditions.
– Limits negative impact of mycotoxins on animals.
– Binds a broad spectrum of major pathogens (E.coli, Salmonella)
thanks to its high content in mannanoligosaccharides (MOS),
reducing their attachment onto the intestinal mucus.
– Helps to raise animal natural self defenses • Enhances humoral
immune responses under challenging conditions.
– Improves cell-mediated immune response to disease
– Binds specific mycotoxins avoiding its absorption through the
intestine.
I hope this information has been helpful for you in understand a
little more of the problems you may be experiencing with
your horses.
Please feel free to contact us if we can be of more guidance.